Abstract
NEW STABILITY INDICATING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DETERMINATION OF VILANTEROL AND UMECLIDINIUM BROMIDE IN BULK AND TABLET DOSAGE FORM

Goudagatla Rajesh*, K. Thejomoorthy and P. Sreenivasa Prasanna

ABSTRACT

A simple, Accurate, precise method was developed for the simultaneous estimation of the Umeclidinium and Vilanterol in bulk and pharmaceutical dosage form. Chromatogram was run through Altima C18 150 x 4.6mm, 5.0. Mobile phase containing Buffer 0.01N Na2hpo4: acetonitrile taken in the ratio 60:40v/v was pumped through column at a flow rate of 1.0 ml/min. Temperature was maintained at 30°C. Optimized wavelength selected was 265 nm. Retention time of Umeclidinium and Vilanterol were found to be 2.280 min and 2.857 min. %Recovery was obtained as 100.06% and 99.66% for Umeclidinium and Vilanterol respectively. LOD, LOQ values obtained from regression equations of Umeclidinium and Vilanterol were 0.19, 0.31 and 0.58, 0.93 respectively. Regression equation of Umeclidinium is y = 25083x + 17380, and y = 23963x + 2725.2of Vilanterol.

Keywords: Umeclidinium, Vilanterol, RP-HPLC.


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