European Journal of Biomedical and Pharmaceutical Sciences

GENE THERAPY IN CANCER

*Arkadip Halder, Prof. (Dr.) Sattwik Das and Prof. (Dr.) Beduin Mahanti

ABSTRACT

Gene-based therapies for cancer in clinical trials include strategies that involve enhancement of immunotherapeutic and chemotherapeutic approaches. These strategies include ex vivo and in vivo cytokine gene transfer, drug sensitization with genes for prodrug delivery, and the use of drug resistance genes for bone marrow protection from high-dose chemotherapy. Inactivation of on co-gene expression and gene replacement for tumor suppressor genes are among the strategies for targeting the underlying genetic lesions appearance on the cancer cell. A review of clinical trial results to date, primarily in patients with very advanced cancers cross- grained to convivial treatments, indicates that these treatments can mediate tumor recoil with acceptably low toxicity. Vector development remains a critical area for future research. Important areas for future research include modifying viral vectors to reduce toxicity and immunogenicity, increasing the transduction efficiency of non viral vectors, emiliorating vector targeting and specificity, regulating gene expression, and identifying synergies between gene- based agents and other cancer therapeutics.

Keywords: Cancer gene therapy, Gene transfer, Immunotherapy, Oncolytic viro therapy, Viral vectors, Non viral vectors, Gene targeting.