European Journal of Biomedical and Pharmaceutical Sciences

INCIDENCE OF G6PD DEFICIENCY AMONG HEALTHY SUDANESE BLOOD DONORS IN KHARTOUM STATE

Sit Albanat Mohamed Sayed* and Alya Ahmed Salman

ABSTRACT

Background: Glucose-6-phosphatebdehydogenase is an enzyme that protects RBCs from oxidative damage by free radicals in food, drugs, chemicals or infectious conditions. If blood from donors with G6PD deficiency is transfused to patients, it can cause serous case for the patient lead to hemolytic anemia and other complication. Objectives: This study was aimed to detection of Glucose-6-Phosphate dehydrogenase deficiency in appear healthy blood donors and detection of Glucose-6-Phosphate dehydrogenase deficiency in blood donors among age.Materials and methods: A handered EDTA blood samples obtained from blood donors were subjected to screen of G6PD deficiency using spectrophotometer. Results: Out of 40 blood donors, the G6PD status of donors; 8 of them (20%) were found to be deficient in activity, while 32 donors (80%) were found normal. Out of 8 deficient, 4(16.7%) of them in age group 19-32y and 4 belonged to age group 33- 46y had G6PD deficiency. There were no significant differences in G6PD enzyme status in study population when compared to age with p.value=0.399. Conclusion: This study was found the prevalence of G6PD deficiency present in 20% of blood donors.

Keywords: G6PD deficiency, spectrophotometer, Blood donors.