TRANSDERMAL DRUG DELIVERY SYSTEM: A REVIEW
Anupma Yadav*, Swarnima Pandey, Arpita Singh and Amresh Gupta
ABSTRACT
Transdermal drug delivery system/TDDS are topically administered drugs in the form of patches that deliver drugs for systemic circulation at a predetermined and controlled rate. TDDS works very easily and drug is applied within the patch and it is worn on skin for long period of time by this constant concentration of drug remain in blood for long time. It is many types varying from single layer drug in adhesive to multi-layer drug in adhesive and others are reservoir and the matrix systems. Drug delivery through the skin has been always a challenging area for research due to barrier properties exhibit by the outermost layer of skin stratum corneum. In the few decades, TDDS has become a proven technology that offers significant clinical benefits over other dosage forms. Because it offers controlled as well as predetermined rate of release of the drug into the patient, it able to maintain steady state blood concentration. This system is a desirable form of drug delivery because of the obvious advantages like it painless and self-administration, avoidance of hepatic first-pass metabolism and the GI tract for poorly bioavailable drugs over other routes of delivery.
Keywords: Transdermal drug delivery system, bioavailability, Iontophoresis, Electroporation, microscopic projection.
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