Abstract
DEVELOPMENT AND VALIDATION OF Q-ABSORBANCE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TORSEMIDE AND EPLERENONE IN BULK AND COMBINED DOSAGE FORM

Shraddha V. Tathe*, Akshay Suryavanshi, Shubhangi Gaikwad, Shivangi Gupta, Bharat Dawra, Unnati Amale, Shivani Jadhav and Ajit Gaiki

ABSTRACT

A simple, precise, accurate and rapid UV spectrophotometric method has been developed for simultaneous estimation of Torsemide and Eplerenone. A completely newly developed analytical method validation has been developed as per ICH Guidelines. The UV-spectrophotometric method, estimation of Torsemide and Eplerenone was carried at 244 nm and 262 nm by Q- Absorbance Ratio method. The ratio of absorbances are at two wavelengths, one which is an isoabsorptive point and other is the λ max of one of the two components. From the overlay spectra of two drug, it is evident that Torsemide and Eplerenone show an isoabsorptive point at 262 nm. The second wavelength used was 244 nm, which is λ max of Eplerenone.Therefore the method developed for Torsemide and Eplerenone is suitable for simultaneous estimation by UV spectrophotometry.

Keywords: Torsemide, Eplerenone, Q-Absorbance Ratio, Simultaneous Estimation, Method Validation.


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