Abstract
DEVELOPMENT AND VALIDATION OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY METHOD FOR VALSARTAN

Zeinab M. Elrefaey*, Mona F. Arafa, Gamal M. El Maghraby and Mohammed A. Osman

ABSTRACT

To develop an easy assay for the quantitation of valsartan the angiotensin II receptor antagonist. An isocratic separation was conducted by a reversed phase column (ODS) of a 150 mm in length x 4.6 mm with precolumn internal diameter and an average silica particle size of 5m at room temperature. Mobile phase was a mixture of acetonitrile: potassium dihydrogen phosphate buffer solution (70: 30% v/v) at a flow rate of 0.8 mL/min and detected 273 nm. The response to 5–40 g/ml valsartan was linear. The developed method was validated with respect to linearity, accuracy (recovery) and precision. This convenient method is suitable for determination of valsartan.

Keywords: Valsartan, Losartan, HPLC, Validation.


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