Abstract
EFFECT OF ETHANOL EXTRACT OF CELERY (APIUM GRSVEOLENS) ON SOME BIOCHEMICAL PARAMETERS IN ACETAIMINOPHEN INDUCED WISTAR ALBINO RATS FED WITH FATTY DIET

*Olubunmi O. Ezomoh, Peter P. Erigbali and Sule O. Jimoh

ABSTRACT

This study evaluated the effect of celery (Apium graveolens) on paracetamol-induced male albino rats fed with high fat diet. 24 wistar albino rats were grouped into four (4) groups each having six (6) animals. Animals in Group 2, 3 and 4 were fed with high fat diet and induced orally with 750mg/kg body weight of Paracetamol(Acetaminophen) afterwhich group 3 and 4 received 200mg/kg and 400mg/kg of celery (Apium graveolens) extract respectively and group 2 served as positive control. Biochemical analysis revealed that induction of paracetamol resulted in significant increase (p<0.05) in ALT and AST in positive control (1510.67±11.36 and 75.4 ± 3.2) respectively when compared with the normal control groups (715.00±18.4 and 63.5 ± 2.6). However, there was a non-significant (p<0.05) decrease in the level of ALP levels in positive control (186.69±4.05). Levels of LDH decreased significantly (p<0.05) in positive control as time progressed from 30seconds to 3minutes (1136.51±13.53 to 1195.56±66.53). ALT and AST significantly decreased in extract treated groups 3 and 4 (498.67±17.96 and 553.67±54.63) respectively compared to positive control (1510.67±11.36). ALP levels increased non-significantly (p<0.05) in extract treated group 3 and 4 (30.89±1.26 and 30.89±1.99) respectively compared to positive control (29.67±1.00). LDH levels increased significantly (p<0.05) in extract treated groups 3 and 4 as time progressed from 30sec to 3mins (1287.78±14.86 and 1205.77±22.16) respectively compared to positive control (1136.51±13.53 to 1195.56±66.53). However, a non-significant difference was observed in positive control group when compared to normal control. Histopathological examinations of liver sections from normal control group shows normal kidney histology while those in group 2 (positive control) showed damage to hepatocytes, however groups 3 and 4 though similar to the control showed signs of inflammatory cells which is indicative of healing process. Findings from these study shows that the extract of Celery (Apium graveolents) confers some degree of protective function on the liver and biochemical parameters of paracetamol-induced rats fed with high fat diet.Biochemical analysis revealed that induction of acetaminophen resulted in significant increase (p<0.05) in cholesterol and glucose in positive control (301.83±4.82 and 19.03±1.04) respectively when compared with the normal control groups (206.01±2.41 and 39.16±2.08). However, there was a significant (p<0.05) decrease in the level of triglycerides, LDL, Cholesterol and Glucose in test groups 1 and 2 when compared to the positive control (188.62±1.47 and 177.02±2.27), (76.95±0.81 and 20.42±0.79), (242.75±4.54 and 201.51±5.56) and (27.18±0.67 and 19.03±1.04) respectively. However, HDL levels increased (208.33±2.14 and 212.99±2.46). Histopathological examinations of kidney sections for normal control group shows normal kidney histology while those in group 2 (positive control) showed necrosis of the renal cortex, however test groups 3 and 4 though similar to the control have fewer glomeruli. Findings from these study shows that the extract of Celery (Apium graveolents) confers some degree of protective function on the kidney and biochemical parameters of acetaminophen-induced rats fed with fatty diet.

Keywords: Paracetamol, Apium graveolens, Histopathological, Cholesterol, Glucose.


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