European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW ON: PENETRATION ENHANCERS FOR OCULAR DRUG DELIVERY

Dr. Vishal Garg*, Naveen Garg, Dinesh Jindal and Kriti Gupta

ABSTRACT

The eye is a unique organ, both anatomically and physiologically, containing several widely varied structures with independent physiological functions that render the organ highly impervious to foreign substances. Ophthalmic drug delivery is one of the most interesting and challenging endeavours faced by pharmaceutical scientist due to the presence of blood-retinal, blood-aqueous humour and blood-vitreous humour barriers. The most commonly used dosage form in treating ocular diseases is locally administered eye drops. Topical administration of drugs is beneficial for delivery to the anterior (cornea, conjunctiva, sclera, anterior chamber) as well as posterior (vitreous humor, retina, choroid) segments of the eye.[1] Permeation of a compound via the conventional mode of ocular drug administration, the topical drop, is opposed by precorneal and corneal barriers. Pre-corneal barriers include formulation drainage; blinking; tear film; tear turn-over; and formulation-induced lacrimation. The corneal pathway is considered a major pathway for drug entry into the anterior and posterior segment of the eye.

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