Abstract
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF FEXOFENADINE HYDROCHLORIDE: A REVIEW

Sarang V. Dalvi* and Dr. Vikrant P. Wankhade

ABSTRACT

Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast-disintegrating tablet of Fexofenadine Hydrochloride for allergic and respiratory disorders. As precision of dosing and patient's compliance become important prerequisite for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient's acceptability. Hence, the present investigation was undertaken with a view to develop a fast-disintegrating tablet of Antihistamine Drug which offers a new range of products having desired characteristics and intended benefits. Super disintegrants such as Sodium Starch Glycolate were optimized. Different binders were optimized along with optimized super disintegrant concentration. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content. Optimized formulation was evaluated by in vitro dissolution test, drug excipient compatibility and accelerated stability study. It was concluded that fast disintegrating tablets of Antihistamine Drug were formulated successfully with desired characteristics which disintegrated rapidly, provide rapid onset of action, and enhance the patient convenience and compliance.

Keywords: Fast dissolving tablets, Fexofenadine Hydrochloride, Antihistamine Drug, Super disintegrants, Cross Povidone.


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