European Journal of Biomedical and Pharmaceutical Sciences

ENHANCEMENT OF DISSOLUTION RATE OF POORLY WATER SOLUBLE DRUG BY USING SOLUBILITY ENHANCEMENT TECHNIQUES

Nandkumar S. Damaranche*, Vikrant P. Wankhade, Sarang V. Dalvi and Smita Mankar

ABSTRACT

Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. Solubility is important parameter to achieve desired concentration of drug in systemic circulation for maximum pharmacological response. Poorly water-soluble drugs require high doses in order to produce desired therapeutic action after oral administration. Poor aqueous solubility is a major problem encountered with development of new chemical entities. There are over 40% of new chemical entities that having a poor solubility and low bioavailability. As per BCS classification system, these drugs comes under BCS class II that show poor solubility and high permeability. The bioavailability of these drugs can be improved by increasing the solubility and dissolution rate of these drugs. This review article focusses on number of methods for increasing the solubility and dissolution rate of poorly water-soluble drugs.

Keywords: Solubility, Dissolution rate, BCS class II drugs, Solubility enhancement, Bioavailability.