European Journal of Biomedical and Pharmaceutical Sciences

BEHAVIOURAL AND NEUROPHARMACOLOGICAL EFFECTS OF HEDYCHIUM SPICATUM IN EXPERIMENTAL ANIMAL

Tarique Aziz*, Daniyal Abdullah, J. V. Vyas, A. M. Wankhade and V. V. Paithankar

ABSTRACT

Hedychium spicatu. (Family Zingiberaceae) is a rhizomatous herb, used in medicines, food, cosmetics and perfumery industries. Traditionally, it is widely used in treating inflammation, pain, asthma, foul breath, vomiting, diarrhoea, bronchitis, hiccough and blood diseases. This study systematically reviewed traditional and folk uses, pharmacological properties, bioactive compounds and market potential of H. spicatum. Research gaps and potential of future research have also been discussed here we studied neuropharmacological and Behavioral changes by this plant The acute oral toxicity study conducted as per the OECD guideline did not show any toxicity as per its acceptable range for both extracts of HS (EHS and PHS). The initial behavioral observations did not revealed any gross change in the animal behavior treated with the extracts of the plants. However i reduction in alertness, reaction to touch stimuli and righting reflex was reported evident in EHS. ethanolic extract of HS exhibited significant reduction in basal activity count as well as the fall off time. Ethanolic extract of both the plants did not show any significant change in latency period in hot plate method. Although the significant increase in the reaction time with ethanolic extract of HS was observed but absence of straub tail phenomena ruled out the narcotic analgesic action. The increased reaction time may be due to the sedative effect. ethanolic extract of HS showed significant dose dependent (dome shape curve) activity. The results of anticonvulsant activity evaluated against MES induced convulsions both acute as well as chronic studies revealed ineffectiveness of bothe the extracts towards prevention of convulsions. The antianxiety action of the rhizomes of HS may due to presence of saponin. The results further suggested the possible use of these plants in various related bahavioral and neurological complaints.

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