European Journal of Biomedical and Pharmaceutical Sciences

STUDIES IN DEVELOPMENT OF BICALUTAMIDE NANOFORMULATIONS

Dr. Rakesh P. Patel*, Vishal A. Bhavsar

ABSTRACT

Bicalutamide (BIC) is an anti-cancer drug having poor water solubility and low bioavailability. The aim of present work was to increase solubility of BIC which may increase the bioavailability. Nanoformulations of BIC such as Nanoparticle, Solid Lipid Nanoparticle (SLNs) and Nanocrystals were prepared and evaluated for physicochemical characteristics. Finalised Nanoformulations were compared with respect to Solubility, In-Vitro drug release, In-Vitro cytotoxicity and Bioavailability study. From the physicochemical characterization and evaluation of all nanoformulations, it was observed that Polylactic-co-glycolic acid (PLGA) Nanoparticles prepared using high pressure homogenizer has higher increment in the solubility compare to SLNs and Nanocrystal of BIC. Cytotoxicity Study showed that PLGA Nanoparticles have higher bioavailability as well as higher % Cell inhibition. In a nutshell, Nanoformulation such as PLGA Nanoparticle is one of the promising approach to enhance the Bioavailability of BIC.

Keywords: Bicalutamide (BIC), Nanoparticles, Solid Lipid Nanoparticles (SLNs), Nanocrystals, Cytotoxicity, Bioavailability, Poly lactic-co-glycolic acid (PLGA).