EVALUATION OF ANTI-ULCER ACTIVITY OF INDAZOLE AND ITS DERIVATIVES
Dr. Asif Rasheed*, Rubeeya Lodhi, Shaheen Begum, Sadia Fatima, Shaheen Banu, Shaik Ilyas, Syeda Zehra Raza
ABSTRACT
The biological activities of the heterocyclic compound, indazole, including anti-inflammatory, antimicrobial, anti-HIV, anticancer, hypoglycaemic, antiprotozoal, antihypertensive, and other activities. From the observed biological activities of the indazole moiety, it is concluded that the medicinal properties of indazole have to be explored in the near future for the treatment of various pathological conditions. The present study is concerned with exploring the potential pharmacological actions of indazole and its derivatives. The main focus is on their role in ulcer protective effect against pylorus ligation-induced gastric ulceration, Swimming stress induced ulcers, Aspirin induced ulcer in rat modal. The present study identified that, all investigated compounds may prevention of pylorus ligation-induced gastric ulceration, Swimming stress induced ulcers, Aspirin induced ulcer. They can be combined with any of the currently used NSAIDS to improve its therapeutic efficacy and at the same time to blunt /offset gastric ulceration, the most feared adverse effect of NSAID. All tested compounds have ulcer protective effect induced by pylorus ligation, Swimming stress, aspirin. 6-Nitroindazole have better activity compared with Indazole and 5-Amino indazole.
Keywords: Indazole, 5-Amino indazole, 6-Nitroindazole, Anti-ulcer activity, NSAID.
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