FORMULATION, CHARACTERIZATION AND PROTEIN TYROSINE PHOSPHATASE-1B (PTP1B) INHIBITORY ACTIVITY OF POLYHERBAL TABLET
Dr. Prashant Soni* and Dr. Yogesh Shivhare
ABSTRACT
The present study involves preparation and characterization of polyherbal tablet followed by evaluation for Protein Tyrosine Phosphatase-1B (PTP1B) inhibitory activity as a preliminary anti-diabetic potential of formulation. The polyherbal tablet prepared from methanolic extracts of Carissa carandus, Moringa oleifrea, Ocimum sanctum and Manilkara zapota. The extracts of plants were mixed with other excipient as per the prerequisite parameters of wet granulation method and finally compression machine was utilized to prepare polyherbal tablet. Tablets were prepared by varying compositions of ingredients and in this way four different tablets formulations (F1, F2, F3 and F4) were prepared. This herbal formulation was evaluated for its preliminary anti-diabetic potential using PTP1B enzyme inhibitory activity which was performed on in-vitro assay kit. The findings of study revealed success of formulation method since all characteristics parameters of tablet formulations were observed within the acceptable range. Moreover formulations F1 & F3 exhibited appreciable PTP-1B inhibitory activity with percentage inhibition 73.33% and 69.75% respectively. This result suggested probable anti-diabetic potential of polyherbal tablet formulation.
Keywords: Carissa carandus, Moringa oleifrea, Ployherbal, Anti-diabetic, PTP-1B.
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