European Journal of Biomedical and Pharmaceutical Sciences

AZITHROMYCIN INDUCED URTICARIA REACTION: A RARE CASE REPORT

Bushrah Anjum B.*, Roshan Jameer B., Siddarama.R, Sravanthi D., Asif S. K., Ganesh Reddy V.,
Parveen S.

ABSTRACT

Azithromycin is a mostly preferable antibiotics is effective against a wide assortment of bacteria organisms, such as Hemophilus influenza, Mycoplasma pneumonia, Streptococcus pneumoniae, mycobacterium avium, and Staphylococcus aureus. Which is commonly used antibiotic in patients with various infections like pain during urinating or having sex, unusual vaginal discharge bleeding between periods, pain of below belly button and unusual lumps, bumps, blisters or sores around the genital or anal area. Hypersensitive reactions subsequent azithromycin therapy is unusual but is potentially life-threatening. It is rapidly occurring reactions, hence called immediate hypersensitivity reactions. Whenever the patient exposure to certain drugs (penicillin, cephalosporin's and aspirin) production of IgE antibodies – fix to mast cells then again re-exposure to the same drug antigen-antibody reaction occurs on the mast cell surface then release of inflammatory mediators like histamine, 5-HT, PGs, LTs, PAF these mediators cause the hypotension, bronchospasm, angioedema, urticarial, rhinitis and anaphylactic shock. The management of hypersensitivity (urticaria) reactions. This can manage to stop the drug and by providing symptomatic treatment like anti histaminic therapy and antibiotics.

Keywords: Azithromycine, urticaria, adverse drug reaction, hyper sensitivity reaction.