European Journal of Biomedical and Pharmaceutical Sciences

MUCORMYCOSIS DUE TO UNCONTROLLED DIABETES A CASE REPORT

Pravalika Dubasi*

ABSTRACT

Mucormycosis is also known as black-fungus. It is a difficult-to-manage infection and has limited diagnostics tools and therapeutics options. The incidence of mucormycosis is increasing. It is earlier called zygomycosis. The diagnosis and treatment of mucormycosis is challenging. It mainly affects those who are immunocompromised and the patients with uncontrolled diabetes and patients including hematological malignancies, Neutropenia. The disease manifest through rhinocerebral and pulmonary disease. Early recognition of fungal infection is critical for the treatment to be success and initiation of antifungal therapy with loposomol Amphoterecin B is the drug of choice for antifungal treatment, Posoconazole, Isavuconazole. Successful management of mucormycosis is based on reversal or discontinuation of predisposing factors and early administration of active fungal agents and complete removal of infected tissues. The mortality rate of the disease remains high. It has limited clinical experience are iron chelation and immunotherapy. The pathology is understanding by diagnostic tools including computed tomography and serum polymerase chain reaction, cultures are the corner stones of diagnosis and therapeutic options.

Keywords: Mucormycosis, PCR, Liposomal amphotericin B, Isavuconazole , Posaconozole, Zygomycosis, Diabetes mellitus, fungal infection, Black fungus.