Abstract
POTENTIAL ANTIOXIDANT EFFECT OF A PREPARATION OF TWO PLANTS (DISTEMONANTHUS BENTHAMIANUS AND DISSOTIS ROTUDIFOLIA)

Adélaide Ryta Mande Doue, Cassime Tiemoko*, Bernard Tehi Sea, Honoré N'Guessan Yao, Alain Dit Philippe Bidie

ABSTRACT

Background: Plants are sources of natural antioxidants and some of their compounds have important antioxidant properties and health benefits. Distemonanthus benthamianus and Dissotis rotundifolia are used in traditional medicine for the treatment of many diseases. Objective: To evaluate the in vitro and in vivo antioxidant potential of extracts from a preparation of a mixture of D. benthamianus stem bark and D. rotundifolia leaves in diabetic rats. Methodology: Total phenols and flavonoids in the extracts were determined using spectrophotometric methods. In vitro antioxidant activity was determined by DPPH method and ABTS+ assay. Rats (25) were used for the evaluation of the in vivo antioxidant activity. These animals were divided into 04 batches (05) made diabetic and one control batch (05). After 21 days of treatment with the different extracts, these animals were sacrificed and the markers (SOD, Catalase, MDA and TBars content) were measured. Results: We note a strong presence of phenolic compounds and flavonoids in the hydroethanolic extract compared to the aqueous extract. This extract also showed a strong antioxidant activity in vitro (IC50 = 115.38 ug/ml and % =51.46 mg TE/g) in contrast to the aqueous extract (IC50 = 167.74 ug/ml and % =37.21 mg TE/g). Furthermore, the in vivo activity showed a better regulation of stress markers with the hydroethanolic extract. Conclusion: The extracts seem to have a promising antioxidant potential which can be used as a complementary treatment to various oxidative stress related diseases including diabetes.

Keywords: Antioxidants, plants, phenolic, flavonoids, oxidative damage.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • EJBPS: JULY ISSUE PUBLISHED

    JULY 2021 Issue has been successfully launched on 1 July 2021

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT