Abstract
ANALGESIC INTERACTION BETWEEN INTRATHECALLY ADMINISTERED BUPIVACAINE AND EPIBATIDINE IN RATS

*Tomoki Nishiyama MD, PhD

ABSTRACT

Background: We investigated the interaction between intrathecally administered bupivacaine and epibatidine, a nicotinic acetylcholine receptor agonist, on analgesic effects in acute thermal and formalin induced pain models of rats. Methods: Male Sprague-Dawley rats implanted with lumbar intrathecal catheters were given intrathecal combination of 1/2, 1/4, 1/8, and 1/16 50% effective doses (ED50s) of bupivacaine and epibatidine, then tail flick test or formalin test was performed. Isobolographic analysis was done using ED50s, and total fractional dose values were calculated. Behavioral side effects were checked. Results: In the tail flick test, ED50 of the combination was not obtained. Dose dependent decreases of number of flinch response were observed in the formalin test. The ED50s of both phase 1 and 2 of the formalin test were significantly lower than the theoretical additive values. Side effects were not observed in this study. Conclusions: Intrathecal bupivacaine and epibatidine had antagonistic effects on thermal induced acute pain, but synergistically analgesic for inflammatory induced acute and chronic pain.

Keywords: Analgesia, nicotinic acetylcholine receptor, epibatidine, bupivacaine, spinal cord.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • EJBPS: JULY ISSUE PUBLISHED

    JULY 2021 Issue has been successfully launched on 1 July 2021

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT