European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF OXIDANT, ANTIOXIDANT STATUS, SERUM LIPID AND THYROID PROFILE IN NON-PREGNANT, PREGNANT AND PRE-ECLAMPTIC WOMEN.

Dr. Jyoti Batra*, Sudeep Kumar, Dr. Alpana Agarwal, Dr. Manisha Arora, Suyash Saxena, Roshan Kumar Mahat

ABSTRACT

Background: Pre-eclampsia can be defined as, increased blood pressure with proteinuria, edema or both. Normally pregnancy is associated with oxidative stress and this is increased during pre-eclampsia. Aim: The aim of our study was to evaluate oxidative stress, serum lipid and thyroid profile in healthy non pregnant, pregnant and pre-eclamptic women. Method: Our study included 75 subjects out of which 25 were non pregnant, 25 were pregnant and 25 were pre-eclamptic women. All pregnant women were at ≥30 weeks of gestation. The lipid parameters were estimated by enzymatic method, MDA level was estimated by thiobarbituric acid (TBA) method, Thyroid profile (T3, T4 and TSH) were measured using CLIA system and vitamin E was estimated by the method of Baker et al. Result: The mean serum T3 and T4 in normally pregnant woman were significantly higher when compared with non-pregnant women. In women with preeclampsia, the mean serum T3 and T4 were significantly higher when compared with non-pregnant women. The mean serum T3 level decreased significantly in preeclamptic women when compared to normally pregnant while mean T4 level increased non-significantly in pre-eclamptic women when compared with healthy pregnant women. The mean TSH level increased significantly in pre-eclampsia when compared either with healthy non-pregnant or with normal pregnant women. The mean serum Total Cholesterol, Triglyceride, LDL-c, VLDL-c and MDA levels increased significantly in pre-eclampsia when compared either by non-pregnant or normal pregnant women while the levels of Vit-E and HDL-c decreased significantly in pre-eclampsia when compared with normal pregnant women.

Keywords: Pre-eclampsia, Oxidative Stress, Lipid profile, Thyroid function, Vitamin E.