European Journal of Biomedical and Pharmaceutical Sciences

TO EVALUATE THE LEVELS OF HOMOCYSTEINE AND ZINC IN PATIENT WITH VARIABLE DURATION OF TYPE 2 DIABETES MELLITUS.

Rehan Majeed*, Iftikhar Ahmad, Muhammad Sarwar, Saba Iqbal and Anila Jalil

ABSTRACT

The purpose of present study was to explore the association of Homocysteine (Hcy) status and zinc levels in diabetic Patients of different duration. The levels of reactive oxygen species and oxidized products in diabetic patients are concern for the complication of the diabetes. Elevated (Hcy) blood levels are responsible for endothelium damage causing blood vessel inflammation which in turn may lead to atherogenesis and resulting ischemic injury. The toxic influence of Hcy to the endothelium can be blocked by antioxidant enzyme supplementation. To achieve this objective diabetes mellitus type 2 patients(DMT2) were divided into 3 groups and controls based on duration of sufferings from diabetes. Total 120 subjects, 30 were assigned as control, (group 1) and 90 of DMT2. Patients of DMT2 were divided into; group 2 (DMT2 <5 years), group 3 (DMT2 = 5-10 years) and group 4 (DMT2 >10 years). DMT2 was diagnosed according to guidelines of American Diabetes Association. It was found that the levels of circulating homocysteine were considerably higher in patients having type2 diabetes. Moreover, It was interestingly noted that the serum homocysteine level rises with the long duration of diabetes. A rise of Hcy in plasma has been recognized as a threat for many complications in diabetes. Alteration of total antioxidant profile along with levels of zinc in different durations of diabetes has been a major focus of current research.

Keywords: Homocysteine, Reactive oxygen species, Diabetes Mellitus Type 2 (DMT2), Atherogenesis.