A REVIEW ARTICLE OF HARD CANDY LOZENGES
Renu M. Awachar*, Pragati R. Katkide, Satish R. Tayghan and Sandeep C. Atram
ABSTRACT
Recent developments in rapidly disintegrating tablets have brought convenience in dosing to pediatric and geriatric patients who have problem in swallowing tablets. The objective of the present study was to prepare the rapid-disintegrating tablet of Cetirizine Hydrochloride for allergic and respiratory disorders. As precision of dosing and patient's compliance become vital prerequisite for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient's acceptability. so, the present investigation was undertaken with a view to develop a fast-disintegrating tablet of Antihistamine Drugwhich offers a new range of products having desired characteristics and intended benefits. Super disintegrants such as Sodium Starch Glycolate were optimized. Different binders were optimized along with optimized super disintegrant concentration. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content. Optimized formulation was evaluated by in vitro dissolution test, drug excipient compatibility and accelerated stability study. It was concluded that rapidly disintegrating tablets of Antihistamine Drug were formulated successfully with required characteristics which disintegrated rapidly, provide rapid onset of action, and increase the patient convenience and compliance.
Keywords: Fast dissolving tablets, Antihistamine Drug, Super disintegrants, Cross Povidone.
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