European Journal of Biomedical and Pharmaceutical Sciences

BIOMECHANISM OF HEALING AFTER GUIDED BONE REGENERATION THERAPY

Dr. Urvashi Verma MDS, Dr. Syed Owais Ahmed MDS, Dr. Kinjal Kanubhai Desai MDS, Dr. Unnati Oza
MDS, Dr. Harsh Parikh MDS, *Dr. Babu Salam MDS

ABSTRACT

Following GBR procedure, bone regeneration exhibits a specific sequence of events. Within the first 24 hours, the graft material/barrier created space is filled with the blood clot which releases growth factors (e.g., platelet derived growth factor) and cytokines (e.g., IL-8), which in turn attracts neutrophils and macrophages. The clot is gradually absorbed and replaced with granulation tissue which is rich in newly formed blood vessels. Through these blood vessels, nutrients and mesenchymal stem cells capable of osteogenic differentiation can be transported to the defect site, which contribute to osteoid formation. The osteoid mineralizes and forms woven bone, which later serves as a template for the apposition of lamellar bone. This transformation of primary sponge work would eventually constitute both compact and reticular bone with mature bone marrow. These events occur 3 to 4 months postsurgery.

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