Abstract
REVIEW ON NITAZOXANIDE: A BROAD SPECTRUM ANTIPARASITIC AGENT

Ruchita M. Kothari*, Dr. Javesh K. Patil, Akash S. Jain, Hitendra S. Chaudhari, Amitkumar R. Dhankani and Yogesh B. Rokade

ABSTRACT

Nitazoxanide is a thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of parasites as well as some bacteria. It has been used as a single agent to treat mixed infections with intestinal parasites i.e. protozoas and helminths. It was originally discovered in 1975 by Jean Francois Rossignol & It was initially developed as a veterinary antihelminthic with activity against intestinal nematodes, cestodes, and liver trematodes & In humans, nitazoxanide has been reported to be effective against a broad range of parasites, including Giardia lamblia, Entamoeba histolytica, Cryptosporidium parvum, Cyclospora cayetanens, etc. The main objective of this review is to study detailed profile of nitazoxanide like physicochemical properties, pharmacokinetics, clinical uses, and adverse effects of Nitazoxanide.

Keywords: Nitazoxanide, Antiparasitic agent, protozoa, helminths, etc.


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