European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING TABLET FOR ANTI-ASTHMATIC DRUG

Shubhangi Zanak Jadhav*, Nishan N. Bobde, Vivek S. Harbade and Abhishek Patle

ABSTRACT

Objective: This research was aimed at to formulate and evaluate oral fast dissolving tablets of montelukast sodium using superdisintegrants at variable concentrations. Methods: In the present study, the oral fast dissolving tablets of Montelukast Sodium were formulated using direct compression method incorporating microcrystalline cellulose (MCC) as direct compressible diluents after finding encouraging results of prefomulation studies. Sodium starch glycol ate (SSG) and Crosprovidone were selected as superdisintegrants seeing their minimum dissolution time. Six formulations were prepared using varied concentrations of superdisintegrants. The investigations of these formulations were aimed to look into their influence on the disintegration time and dissolution rate of these tablets and other evaluation parameters were also evaluated. Results: Fast dissolving tablets of montelukast sodium were prepared with crosprovidone and SSG had a shorter disintegration time or dissolution time and gives the best pharmaceutical performance. The evaluation of formulations reflected good pre and post-compressive characteristics.

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