European Journal of Biomedical and Pharmaceutical Sciences

ASSESSMENT OF PRESCRIPTION PATTERNS IN PATIENTS WITH HYPERTENSION AND DIABETES MELLITUS IN A TERTIARY CARE HOSPITAL IN SOUTH INDIA

Lakshmi Suresh*, Neeraja S. Muraleedharan, Suhail M., Swathi M., Dr. Anilasree B.P. and Dr. G. Babu

ABSTRACT

Objective: To analyze the prescription pattern of diabetic and hypertensive patients, ADRs, drug-drug interactions of anti-hypertensive and anti-diabetic drugs. Assess whether mono therapy or combination therapy used in prescription. Methods: A prospective observational study conducted during a study period of 6 months among 107 inpatients with hypertension and diabetes mellitus. Results: Among the data of 107 patient with both hypertension and diabetes 59 (55.14%) were male and 48 (44.85%) were female. Commonly prescribed antihypertensive was telmisartan which was prescribed 44 times in patients prescription (41%), amlodipine prescribed 23 times (21.4%). Commonly prescribed antidiabetic drug was metformin which was prescribed 77times (71.9 %), Insulin injection Human Actrapid prescribed 20 times (18.6%.) The least prescribed drugs is Vildagliptin 1 time (0.9 %.). Moderate drug-drug interactions were found to be 28, Minor dug-drug interactions is 12 in number. Commonly seen adverse drug reactions like hypoglycemia and hypotension were observed. The number of prescriptions with antihypertensive drugs given as combination therapy was 61 and monotherapy was 46 and in antidiabetic drugs given as combination therapy was 67 and monotherapy was 40. Conclusion: This study has analyzed the prescription pattern and the most common therapeutic treatment given to the patients with hypertension and diabetes mellitus along with drug- drug interactions, ADR, combination and mono therapy of hypertension and diabetes mellitus.

Keywords: Hypertension, Diabetes Mellitus, Drug- Drug Interaction, Adverse Drug Reaction, Combination Therapy, Mono Therapy, Antihypertensive, Anti-Diabetics Drugs.