INVESTIGATION OF IN- VIVO ANALGESIC AND IN-VITRO THROMBOLYTIC ACTIVITIES OF HYDRO ALCOHOLIC LEAF EXTRACT OF Musa balbisiana
Atluri Bhavana*, U. Mounika Sarojini, G. Loka SwarnaDeepika, Y. Krishna Sukanya, V. Sri Lakshmi Sai Gayatri, Shaik Farhatunnisa Begum and K. Padmalatha
ABSTRACT
The plant under investigation (Musa balbisiana) was a giant monocotoyledenous herbs and belongs to the family Musaceae. The goal of our investigation was to determine whether the leaf extracts of this plant held any significant medicinal properties. Leaves of Musa balbisiana were extracted with hydroalcohol. The extracts and fractions were tested for phytochemical analysis, analgesic activity was evaluated employing the eddy’s hot plate and thrombolytic activity was evaluated by the clot lysis test. The extract of all the fractions and streptokinase (standard) exhibited significant clot lysis. The hydro alcoholic leaf extract and fractions produced significant analgesic effects as evaluated. In the hot plate method the extract produced a significant (p < 0.001) dose dependent reduction of thermally induced pain. The overall results suggested that this plant deserves further investigation to isolate the active compounds which are responsible for these activities and to establish the mechanism of action.
Keywords: Phytochemical, Musa balbisiana, Eddy’s hot plate, Thrombolytic activity.
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