FORMULATION AND EVALUATION OF ITRACONAZOLE MUCOADHESIVE TABLETS
Addanki Anusha*, Asma Begum, D. lingamurthi and G. Sowjanya and B. Jhansi
ABSTRACT
Bioadhesive buccal delivery of drugs is most beneficial especially for drugs that experience first pass effect. Administration of the medication via the buccal route will overcome problems such as drug degradation in the harsh gastrointestinal environment, parenteral administration inconvenience. Production of Itraconazole tablets for the delivery of bioadhesive buccal drugs is one of the alternative routes of administration to prevent first-pass effect and provide sustained release. Itraconazole experiences first-pass liver metabolism. This is the reason Itraconazole has lower bioavailability. This molecule meets general considerations about the distribution of buccal drugs. Therefore, it is selected as a drug candidate for the delivery of bioadhesive buccal drugs. A mixture of carbopol 934 and 1:1 ratio hydroxyl propyl cellulose is with complementary physical properties. From the tests, it was concluded that drug release in vitro, resistance to bioadhesion, ex vivo residence time of optimized formulation is suitable for buccal delivery. The pattern of release preceded non-fickian diffusion with release of first volume.
Keywords: Itraconazole, Mucoadhesive, Buccal, Carbopol.
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