Abstract
DESIGN FORMULATION AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM: A RESEARCH

*Pawan Bramhadeo Tripathi and Dr. S. D. Pande

ABSTRACT

Metoprolol succinate sustained release tablet is a beta-1 (cardio-selective) adrenoceptor- blocking agent formulated to provide controlled and predictable release of metoprolol. The pharmacokinetics, efficacy, and safety/tolerability of the antihypertensive combination tablet, essentially reflect the well-described independent characteristics of each of the component agents. The aim of present work was to develop a robust formulation of Metoprolol Succinate sustained Release matrix tablets. The drug product developed to reduce Hypertension. Metoprolol Succinate is an antihypertensive (cardio selective b-blocker) used in the management of hypertension, angina pectoris and heart failure in doses ranging from 25 mg to 200 mg. It is most widely used drug for the treatment of hypertension in USA and America.

Keywords: Antihypertensive drug, sustained release tablets, polymers, Hypertension.


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