A REVIEW ON “SUSTAIN RELEASE MATRIX TABLET BY USING NATURAL POLYMER
*Satish R. Payghan and S. C. Atram
ABSTRACT
The oral route of drug delivery is the most preferred route for administration of drugs. The rationale for the development of a sustained release formulation of a drug is to enhance its therapeutic benefits, minimizing its side effect while improving the management of the diseased condition. Sustained drug delivery systems significantly improve the therapeutic efficacy of drugs. Drug-release-retarding polymers are the key performers in such systems. Nifedipine is a 1,4-dihydropyridine calcium channel blocker. It is used for the treatment of angina pectoris, hypertension, and Raynaud’s phenomenon. Nifedipine has a half-life of 2 hrs. Organoleptic properties, melting point determination, solubility studies, FT-IR frequencies showed that the Nifedipine used was similar to the reported values. After the comparison of FTIR results, it was concluded that there was no incompatibility between drug and polymers. Natural gums like Guar gum and Xanthan gum were chosen as polymers for the formation of sustained release matrix tablets. In this study, 12 formulations were prepared by direct compression method using different polymers at varying ratios, Microcrystalline cellulose and HPMC E5 were used which helps in the slow erosion of matrix from the tablet and Talc and Magnesium stearate as lubricants
Keywords: Sustained release, Nifedipine, Guar gum, Xanthan gum, Matrix tablet.
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