European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF Pterocarpus erinaceus STEM BARK EXTRACTS ON LIVER IN MALARIA INDUCED ANAEMIC MICE

Peter I.*, Modibbo A. A. and Musa M. G.

ABSTRACT

This study is aimed at the effect of Pterocarpus erinaceus stem bark extracts on liver function makers in malaria induced anaemic mice. The mice were divided into six groups of seven mice each. Mice were induced with Plasmodium bergei of 1 x 107 infected erythrocytes. The result shows that there is significant (P>0.05) increase in AST (from 37.43 to 9.57), ALT (from 32.21 to 6.86), total proteins, albumin, bilirubin, glucose (from 36.51 to 5.11), and lipid peroxidation (from 35.70 to 13.70) in malaria control compared to normal control. The group IV to VI were treated with 250 and 500 mg/kg Body weight of both aqueous and ethanolic extracts of Pterocarpus erinaceus stem bark respectively for three days shows significant (P>0.05) decreased in all the parameters tested when compared to malaria control group, but there was dose dependent. The aqueous and ethanolic Pterocarpus erinaceus stem bark extracts have shown to contract the liver injury cause by Plasmodium bergei.

Keywords: Plasmodium bergei, Pterocarpus erinaceus, Liver function test.