Abstract
FORMULATION AND EVALUATION OF CONTROLLED RELEASE MICROSPHERE

*Jaya Madge and S. D. Pande

ABSTRACT

Aim: The aim of present study was formulation and evaluation of Perospirone loaded controlled released microspheres by solvent evaporation technique. Method: Gellon gum is biocompatible polymer used as a retardant material. Drug loading, polymer type and solvent type, such process conditions were investigated. The formulated microspheres were characterized for their particle size, drug release, drug loading. The in vitro studies were carried out. The prepared microspheres were free flowing, white in color, free flowing with spherical shape. Entrapment efficiency of microspheres was found in the range between 34.5 to 53%. The formulation F2 had highest cumulative drug release of 98.26% as compared to other formulation. Conclusion: The study concluded that, the prepared microspheres formulation of gellan gum is better for the formulation of controlled release microspheres of Perospirone.

Keywords: Pulsatile drug delivery, Perospirone, Antipsychotic, Solvent evaporation technique.


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