Abstract
PHARMACOLOGICAL SCREENING OF EDIBLE UNRIPE FRUIT EXTRACT OF MUSA BALBISIANA FOR HEPATOPROTECTIVE ACTIVITY

Suresh Arumugam*, Anupam Prahlad, Mohamed Shibli PC, Hashly Parveen, Venkatesh Sellamuthu and Anjitha P.

ABSTRACT

The objective of the present study was to evaluate the hepatoprotective activity of edible unripe fruit extract of Musa balbisiana. The edible unripe fruits were chopped into small pieces and were dried in shade. The powdered drug was extracted with water by cold maceration technique. The extract was subjected to phytochemical analysis. The In-vitro hepatoprotective activity was assessed by performing MTT assay in Hep G2 Cell lines using Paracetamol as the toxicant. Wistar albino rats of female sex and Aqueous extract of Musa balbisiana (AEMB) at 250 mg/kg and 500 mg/kg and Silymarin (100 mg/kg, p. o.) was used for the study. Paracetamol induced hepatotoxicity was employed to evaluate the hepatoprotective potential of the extract. Biochemical parameters and histopathological examination of liver section were performed. Preliminary phytochemical screening showed alkaloids, flavonoids, tannins, phenolic compounds, terpenoids, saponins, presence carbohydrates, proteins, aminoacids, vitamin C, saponin, starch, and quinones. MTT Assay showed that the extract has a significant protective effect on cell lines against hepatotoxicity and it has increased the cell viability in a dose dependent manner which was further confirmed by morphological assessment. AEMB had shown significant hepatoprotective potential by restoring the biochemical parameters. The same was further confirmed using histopathological studies. The results obtained from the study indicate that unripe fruits of Musa balbisiana possess hepatoprotective due to presence of certain constituents like phenols, flavanoids, vitamin C etc.

Keywords: Musa balbisiana, MTT assay, Hepatoprotective.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • EJBPS: SEPTEMBER ISSUE PUBLISHED

    SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT