Abstract
FORMULATION AND EVALUATION OF ITRACONAZOLE LOADED MICROSPHERE- AS DRUG DELIVERY SYSTEM

Rahul Nagar*, Ajay Kumar and Rishikesh Sharma

ABSTRACT

Microspheres are novel drug delivery system which a very micro particulate and they are designed in such a way which are aimed in lieu of use in control release DDS. They are made of polymers which may belong from natural, synthetic or semi- synthetic origin. Microspheres are identified by free flowing powder which are particle size ranging from 1-1000μm and having proteins in them. The study suggested that ITCZ-MS was formulated successfully by using double emulsification solvent evaporation method. Upon generating various formulations, F8 was optimized amongst to check various parameters such as % yield, % entrapment efficiency and micromeritic properties. The % yield and % EE was 94%, 86% respectively. The various micromeritic properties were found by means of in range and indicating good flow properties of the powder. The morphological characteristics denoted spherical shape and in range size of the microspheres. The drug release profiles showed that maximum amount of drug was released from the formulation which means that it gave good bioavailability and quick onset of action. The drug release kinetics was best fitted in baker Lonsdale model of drug release kinetics in which drug release mechanism was super case II by erosion method.

Keywords: Bioavailability, Double-emulsion, Itraconazole, Microsphere.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • EJBPS: SEPTEMBER ISSUE PUBLISHED

    SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT