European Journal of Biomedical and Pharmaceutical Sciences

A CASE STUDY: ANALYSIS OF ZIKA VIRUS

Nilesh Chougale*, Ajit Kawale and Indrajit Desai

ABSTRACT

ZIKV is one of the rising pathogens in the different geographical regions of the world. More than 84 countries have recently acknowledged the zika virus outbreak. From 2016 to 2019, there were 81,852 confirmed cases of infected patients. Zika virus (ZIKV) is a Flaviviridae family member that has been related to dengue (DENV) and Chikungunya (CHIKV). The genome and virion structure of the Zika virus are both complexes. Virion endocytosis, which facilitates entry into the host cell, is part of its reproductive cycle in the host cell. The infection spreads easily from infected mosquitoes, from a pregnant woman to her fetus, through sexual contact, blood transfusion, and laboratory exposure. In humans, the virus has been linked to foetal microcephaly. There are currently no vaccines available for treatment, but common drugs are recommended for symptom relief. The cross reactivity of the antibodies with other flaviviruses, which leads to antibody-dependent intensification of infection, may make developing an effective vaccine against Zika virus difficult.

Keywords: ZIKA virus, spread, replication, microcephaly, analysis, infection.