European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF TABLETS OF BCS CLASS IV DRUG BY ENHANCING SOLUBILITY USING SOLID DISPERSION TECHNIQUE

Pragati R Katkide*, Sandeep C. Atram and Vivek S. Harbade

ABSTRACT

The poor dissolution characteristics of water insoluble drugs are a major challenge for pharmaceutical science. The objective of this study was to improve solubility, release and comparability of dissolution of a poor soluble drug using solid dispersion two methods. The phenomenon of dissolution of solid phase in liquid phase to obtain a homogenous system is known as solubility. Many drugs, in particular, have poor solubility in water but we also know that water is the chief solvent of choice to be used for liquid pharmaceutical formulations. And thus, this poorly solubility ultimately affects the therapeutic plasma concentrations and also the bioavailability of the drugs. To ameliorate the dissolution of poorly water-soluble drugs as well ultimately ameliorating their bioavailability, the dispersion of one or more active pharmaceutical ingredients in a carrier that too at solid-state is used. This phenomenon is known as Solid dispersion. There are two method use in solubility enhancement Solvent evaporation method and Fusion method with different polymer PEG4000 HPMC with different ratio Solid dispersion of Sulfamethoxazole by solvent evaporation method using HPMC polymer show that increase in solubility and good dissolution as compared to PEG4000. The optimum dissolution was shown by the F5, F10, S5, S9, S10 batches. S10 batch of (solvent evaporation method) 1:5 ratio using HPMC polymer enhance the dissolution rate showing dissolution efficiency comparable to that obtained with F5, F10 batches of fusion method. The study thus presented a system capable of increasing the dissolution rate of Sulfamethoxazole, immediate release formulation is a solution to overcome the variable bioavailability problem of Sulfamethoxazole.

Keywords: Solubility; Solid dispersion; dissolution; solubility enhancement.