European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF AQUEOUS STEM BARK EXTRACT OF KHAYA SENEGALENSIS ON SOME BIOCHEMICAL, AND HAEMATOLOGICAL PARAMETERS IN MALARIA INDUCED ANAEMIC MICE

*Musa M. G., Modibbo A. A. and Idongesit E. E.

ABSTRACT

The use of plants as medicine especially among rural-dwelling, low-income earners has continued to increase because plant materials are affordable and readily available accounting for about 80 % of world population. Khaya senegalensis have been used in tradition medicine for treatment of various ailments such as anaemia and malaria. The effect of Khaya senegalensis stem bark aqueous extract was determined on biochemical, and haematological parameters in malaria induced anaemic mice. The mice were inoculated with 1 x 107 infected erythrocytes containing Plasmodium bergei and grouped into four groups of seven mice each. Groups III and V were treated with 250 and 500 mg/kg body weight of stem bark aqueous extract of Khaya senegalensis. The phytochemical screening shows the presence of Alkaloids, Carbohydrate, Flavonoids, Glycosides, Terpenoids, Steroids, Saponins, Glycosides, Phlobatannins, and Tannins while Anthroquinones was not detected. The result revealed that after five days administration of the extract at the experimental doses resulted into significant (P>0.05) decrease in AST, ALT, total protein bilirubin, urea, creatinine, PCV, WBC, and Lymphocytes compared to malaria control group it was dose dependent. The result of neutrophils shows significant (P>0.05) increase when compared to malaria control group. Khaya senegalensis stem bark extract shown has improved liver and kidney activities and also increased the blood production which may be due to the bioactive phytochemicals present in the leaves extract.

Keywords: Khaya senegalensis, malaria, Liver, kidney, PCV.