European Journal of Biomedical and Pharmaceutical Sciences

METABOLIC OXIDANTS PRECIPITATE THE COMPLICATION OF DM

Dr. Anil Kumar Tiwari, *Dr. Amod Kumar and Dr. Monica

ABSTRACT

Introduction: Diabetes is a metabolic disorder of carbohydrates, protein and lipids resulting into hyperglycemia due to deficiency and absence of insulin. This disorder leads to increased production of free radicals causing causing complications of diabetes. Malon Dialdehyde (MDA) is a biomarker for free radicals mediated lipid damage and oxidative stress.

Aims and Objectives: To study the role of MDA as a primary Biomarker of diabetic complication.

Material and Methods: Study comprised of 50 each of IDDM and NIDDM patients and healthy individual controls. Samples were collected for estimation of Blood glucose and MDA.

Results:-MDA level was found to be elevated in case of  Diabetes and more in case of NIDDM.

Introduction: Diabetes is a metabolic disorder of carbohydrates, protein and lipids resulting into hyperglycemia due to deficiency and absence of insulin. This disorder leads to increased production of free radicals causing causing complications of diabetes. Malon Dialdehyde (MDA) is a biomarker for free radicals mediated lipid damage and oxidative stress.

Aims and Objectives: To study the role of MDA as a primary Biomarker of diabetic complication.

Material and Methods: Study comprised of 50 each of IDDM and NIDDM patients and healthy individual controls. Samples were collected for estimation of Blood glucose and MDA.

Results:-MDA level was found to be elevated in case of  Diabetes and more in case of NIDDM.

Keywords: DM, NIDDM, MDA level, Blood glucose.