European Journal of Biomedical and Pharmaceutical Sciences

BIOCHEMICAL AND INFLAMMATORY BIOMARKERS ABNORMALITY ASSOCIATED WITH MORTALITY IN COVID-19- A RETROSPECTIVE OBSERVATIONAL STUDY IN A TERTIARY CARE CENTRE IN INDIA

Dr. Prakriti Gupta, Dr. Reema Kapoor Mehra ? and Dr. Navpreet Singh

ABSTRACT

Background and objectives: COVID 19 caused by SARS-CoV-2 virus was declared a pandemic by WHO on March 11, 2020. With primary involvement of the respiratory system, it causes ARDS, sepsis, septic shock, metabolic acidosis, coagulopathy, and multi-organ failure in case of severe infection leading to death. Thus comes the role of laboratory analysis of biochemical profile and immune biomarkers in disease management of COVID 19. Method It was a retrospective observational study which was conducted on data of 730 patients who were admitted with COVID 19 in Jayaarogya Hospital Gwalior. Baseline biomarkers were collected which included routine biochemical markers (RFT, LFT and electrolytes) and inflammatory parameters (IL-6, ferritin, Troponin I and procalcitonin). The data was collected and compared between deceased (n=97) and survivors (n=633). Result There was a significant increase in urea, creatinine and uric acid and AST in the deceased group along with significant hypoalbuminemia. All four inflammatory markers were significantly increased in the deceased group. Kaplan-Meier survival curves also showed that patients with IL-6, Troponin-I, or procalcitonin higher than the normal values had a significantly higher probability of mortality (log-rank, P < 0.05). The multivariate Cox model showed that Troponin-I (P = 0.028) could be used as independent factors to predict mortality. Conclusion Laboratory analysis of biochemical profile and immune biomarkers in patients infected with SARS-CoV-2 not only plays a role in monitoring treatment for better patient management in COVID 19 but also in prediction of disease severity and mortality.

Keywords: Biochemical profile, COVID 19, inflammatory markers, Mortality.