Pontea Niaki*, Ishba M. Raja, Sahar Q. Bakhsh, Imran Kalam, Kashmala Shoaib, Marwan Zaarab, Ibrahim Farah and Chaitanya Patel


Introduction: In this study, we tried to find the co-relation between insulin resistance in depression in women. Many studies have been conducted with both men and women and these studies have showed controversial results. Methods: A total of 248 women were taken. 138 participants were diagnosed to have major depression and were on anti-depression treatment. All participants were tested for insulin resistance. Insulin resistance was diagnosed using The American Association of Clinical Endocrinologists Clinical Criteria. Results: It was found that out of 138 patients with depression, 78 patients had insulin resistance and 60 patients did not have insulin resistance. In the control group, 57 participants had insulin resistance and 53 did not have insulin resistance. On performing the chi square test, the p value came out to be 0.01. This value is less than 0.05 and hence the difference in the observation was significant and not due to chance. Conclusion: There is a strong positive association between insulin resistance and depression in women. Female patients with insulin resistance are highly prone to develop depression.

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