European Journal of Biomedical and Pharmaceutical Sciences

CULTURE AND ANTIBIOTIC SENSITIVITY OF ESCHERICHIA COLI ISOLATED FROM PATIENTS WITH URINARY TRACT INFECTIONS

Mohammad Asaduzzaman*, Farha Matin Juliana, Tasnuva Ferdous, Disha Halder, Salma Begum, Mousumi Khatun, Md. Jhaangir Alam, Nazmul Hossain, Biswajit Das and Sakib Hossen

ABSTRACT

Background: Escherichia coli is the commonest cause of community and nosocomial urinary tract infections (UTI). Antibiotic treatment is usually empirical, relying on susceptibility data from local surveillance studies. We therefore set out to determine the levels of resistance to antimicrobial agents amongst all urinary isolates obtained over a 12-month period. Methods: Antimicrobial susceptibility to nalidixic acid, levofloxacine, cefixime, cotrimoxazole, ceftriaxone, ciprofloxacine, gentamicin, colistin, nitrofurantoin, amikacine, meropenem was determined for 1037 Escherichia coli urinary isolates obtained from community and hospitalized patients in Dhaka. Results: High resistance rates were observed against most of the antibiotics examined here. Nalidixic Acid stood to be the most resistant type of antibiotic. 87.58% resistant for males and 76.71% for females. Cefixime 69.37% for males and 52.64% for females. Cotrimoxazole 59.01% for males and 44.64% for females. Ciprofloxacine 24.84% for males and 17.34% for females. Amikacine 12.61% for males and 13.62% for females. Resistance to Amikacine and Meropenem was found to be lower. Conclusiion: With the exception of nadixic acid, resistance to agents commonly used as empirical oral treatments for UTI was extremely high. Levels of resistance to levofloxacine and cefixime render them unsuitable for empirical use. Continued surveillance and investigation of other oral agents for treatment of UTI in the community is required.

Keywords: UTI, Multidrug Resistance, Uropathogen, Antibiotics, Escherichia coli.