Abstract
STABILITY INDICATING HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF ROSUVASTATIN CALCIUM AS BULK DRUG AND IN TABLET DOSAGE FORM

Dipak R Supe, Padmanabh B. Deshpande*, Saurabh Jadhav and Sandeep Swami

ABSTRACT

The present work describes the development and validation of simple, precise and accurate stability indicating high performance thin layer chromatographic method (HPTLC) method for estimation of Rosuvastatin calcium as bulk and in tablet dosage form. Best chromatographic separation was achieved with use of precoated silica gel 60 F254 aluminium plates as stationary phase and mixture of Toluene: Ethyl acetate: Methanol (5: 3: 2, v/v/v) as mobile phase. Densitometric detection was carried out at 242 nm. The drug was subjected to stress conditions of degradation and the method was validated as per ICH guidelines. The developed method shows linearity over a concentration range of 500-2500 ng band-1. The drug was found to be more sensitive towards acidic and thermal stress conditions in comparison to other stress conditions. The proposed method can be effectively applied to accomplish long-term and accelerated stability studies for the determination of rosuvastatin calcium in pharmaceutical formulations.

Keywords: Rosuvastatin calcium, HPTLC, Stability indicating method, Validation.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: JUNE ISSUE PUBLISHED

    JUNE 2024 Issue has been successfully launched on 1 JUNE 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT