European Journal of Biomedical and Pharmaceutical Sciences

AMIKACIN RESISTANCE PATTERN AND AEROBIC BACTERIAL PROFILE IN DIABETIC FOOT INFECTION PATIENTS

Mohammad Asaduzzaman*, Farha Matin Juliana, Sharmin Akhter, Jharna Akter, Nazmunnahar Ruma, Nilufa Yesmin, Tasnuva Ferdous and Sakib Hossen

ABSTRACT

Introduction: The goal of this study was to determine the frequency of bacterial isolates cultured from diabetic foot infections and to assess their amikacin resistance and susceptibility. Methods: A total of 412 diabetic foot lesions were included in this prospective analysis. The antibiotic susceptibility pattern of bacteria isolated from foot lesions was assessed using the Kirby-Bauer disk diffusion method. Results: The most commonly isolated Gram-positive bacteria were Staphylococcus aureus, followed by Enterococcus spp. and CoNS spp.. The most commonly isolated Gram-negative bacteria were Klebsiella spp., Pseudomonas spp., Proteus spp., Escherichia coli, Enterobacter spp., Citrobacter spp., Citrobacter freundii, and Proteus vulgaris. Amikacin was found to be 84.28% sensitive against the highest infection causing Staphylococcus aureus and followed by Klebsiella spp. (75.00%), Pseudomonas spp. (59.57%), Proteus spp. (92.85%), Escherichia coli (93.33%), Enterobacter spp. (100.00%) and Enterococcus spp. (91.30%). Conclusion: The present study confirmed the prevalence of amikacin drug resistant pathogens (17.96%) in diabetic foot ulcers. The diverse bacteria infecting the wound must be evaluated, as well as the antibiotic susceptibility patterns of the isolates from the infected lesion. This information is critical for selecting the right medications, eliminating resistance trends, and lowering healthcare costs.

Keywords: Diabetic foot infection. Polymicrobial infections, Amikacin.