Abstract
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF LURASIDONE HYDROCHLORIDE BY USING SOLID DISPERSION TECHNIQUE

Yelve Shivaji*, Dr. Deeliprao Derle, Sandeep Khatale and Dilip Satwadhar

ABSTRACT

In present work, an attempt was made to formulate fast dissolving tablets of Lurasidone hydrochloride by solid dispersion technique for improving solubility of Lurasidone hydrochloride using PEG 6000. The Lurasidone hydrochloride tablets were prepared by direct compression method using sodium starch glycolate as superdisintegrant polymer.in Solvent evaporation method drug: polymer 1:3 ratio was showed maximum solubility and drug content. The excipient- drug substance compatibility was assessed and there associative behavior was comprehensively studied by FT-IR, Differential Scanning calorimetry (DSC).Pre-compression parameters of the blend and Post-compression parameters of the prepared batches were evaluated and found to be satisfactory. The prepared tablets were evaluated for various physical parameters, In- vitro drug release study was carried out in phosphate buffer (pH 6.8) for 30 min following USP type-II paddle apparatus. Increase in Sodium starch glycolate concentration resulted in a significant decrease in disintegration time. F6 was optimized formulation released 97.01% of drug release within 30 min. and disintegration time 26 second. Hence, F6 were considered as the best formulation. It was concluded that fast dissolving tablets lurasidone hydrochloride formulated and increase solubility and dissolution rate.

Keywords: Lurasidone hydrochloride, solid dispersion, PEG 6000, solubility, dissolution rate, FDT.


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