European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND CHARACTERIZATION OF ANTI-EPILEPTIC DRUG TRANSDERMAL PATCH FOR ENHANCE SKIN PERMEATION

Priyanka Yadav*, Anubhav Dubey

ABSTRACT

The present work was prepared and evaluates the transdermal patch for transdermal delivery of ethosuximide. The ethosuximide is an antiepileptic drug. Patch formulation was optimized by the different concentration of patch polymers (HPMC, PVP, and Ethyl cellulose, PEG400, Tween 80 and Methanol) include in preparation of patches by solvent casting method. The transdermal patch formulation to sustain release of ethosuximide, improve the bioavalibility of drug and patient compliance. In solvent casting method of TDDS (Transdermal drug delivery system) of ethosuximide transdermal patch was fully planned and urbanized by studies. The FTIR (Fourier transform infrared) revealed that no any type of chemical reaction between drug and polymer that are used in the formulation of transdermal patch. The transdermal patches prepare look like a thin, flexible and effortlessly emergence and there physico-chemical properties are observed. All type of preparations is showed better physico-chemical properties such as thinness, weight variation, drug substance and the flop endurance. The In-vitro % drug release from the patch has precious by the type and concentration of the polymer that showed data of % drug release.” From the records the optimize formulation were screened. In those over and above formulation T4 was to be initiated with admiration. The gain In-vitro % drug release rate is 94.26% at the last of 24 hours. In T4 formulation that include methanol and polyethylene glycol to enhance the skin penetration at show maximum drug permeation.

Keywords: Ethosuximide, drug In-Adhesive, matrix type, transdermal patches, Epilepsy.