European Journal of Biomedical and Pharmaceutical Sciences

PHENOTHIAZINE DERIVATIVES AND IT’ S BIOLOGICAL IMPORTANCE: A REVIEW

Miss. Dipika Hiraman Gosavi* and Miss. Snehal Dilip Pawar

ABSTRACT

Phenothiazine are heterocyclic molecules containing two benzene rings linked in a tricyclic system through nitrogen and sulfur atoms. Phenothiazine derivatives having amino alkyl side chain and these are connected to the nitrogen atom of heterocyclic unit playing crucial role in medicinal chemistry. From last few decades a considerable amount of attention has been focussed on synthesis of phenothiazine derivatives and screening them for different pharmacological activities. These moieties are widely employed as antibacterial, antiviral, antiinflammatory, antipsychotic, antitumor, antimicrobial, antihistamine, antioxidant, antitubercular, antidiabetic, anthelmintic, antifungal, anticonvulsant, enzyme inhibitors, tranquilizers agents etc.

Keywords: Phenothiazine, heterocyclic, antimicrobial, antioxidant, antitumor, Antipsychotic.