Gayatri Kakad*, S. G. Jawarkar and M. D. Game


Thiazolidinones, five membered heterocyclic ring and a saturated form of thiazole with carbonyl group on forth carbon has been considered a magic moiety (wonder nucleus) which possess almost broad spectrum of biological activities such as anti-inflammatory, antitroliferative, antihistamic, anti-HIV, hypnotic, anaethetic, anthelmintic, antifungal and aniviral agents as well as CNS stimulants, hence the researchers has synthesized these condensed heterocyclic through different complex pathways as target structures for biological studies. Thiazolidinones are the compound synthesized by following steps such as condensation followed by cyclication of shiff’s, either in a step wise manner or in a one pot under different conditions. Mercatoacetic acid, thiolactic acid, chloroacetyl chloride, potassium thiocyanate, ethylchloro acetate and ammonium thiocyante are the most common reagents used the synthesis thiazolidinones appended of different heterocyclic skeletons. Heterocyclic componds are promissory drugs due to its reported biological activities, for this reasons, thiazolidinones and its derivatives are presented as a new alternatives not only for its inhibitory activities against the parasite but also for its high selectivity level with high therapeutic index. Thiazolidinones have been reported as a building block in organic chemistry an as a scaffolds for drug discovery. Structure of synthesis compounds was confirmed by means of their IR, NMR Spectral data and elemental analysis. Investigation of antimicrobial and antifungal activities of compound was done by liquid dilution method used for the determination of minimum inhibitory concentration. Bacterial strains of Aspergillus niger and Candida albicans were use to as certain the activity used as the standard positive control for antibacterial and antifungal activity respectively.

Keywords: antitroliferative, antihistamic, anti-HIV, hypnotic, anaethetic.

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