Abstract
A BRIEF REVIEW ON CUSHING’S SYNDROME

Rupal Kaushal, Prerana Sahu*, Aditya Kesharwani, Dr. Rajesh Kumar Nema, Harish Sharma and
Gyanesh Kumar Sahu

ABSTRACT

Cushing’s disease is the result of excess secretion of adrenocorticotropic hormone (ACTH) by a benign monoclonal pituitary adenoma. The excessive secretion of ACTH stimulates secretion of cortisol by the adrenal glands, resulting in supraphysiological levels of circulating cortisol. The pathophysiological levels of cortisol are associated with hypertension, diabetes, obesity, and early death. Successful resection of the Cushing’s Disease-associated ACTH-secreting pituitary adenoma is the treatment of choice and results in immediate biochemical remission with preservation of pituitary function. Accurate and early identification of Cushing’s Disease is critical for effective surgical management and optimal prognosis. The authors review the current pathophysiological principles, diagnostic methods, and management of Cushing’s syndrome.

Keywords: Cushing’s syndrome, Treatment, Diagnosis.


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