European Journal of Biomedical and Pharmaceutical Sciences

LIAISON BETWEEN MEAN ARTERIAL PRESSURE AND GFR IN RENAL FAILURE PATIENTS

Dr. Syed Jaffer*, Sumaiya Quadri, Sara Neha, Dr. B. Sudhakar  and Dr. Anupama Koneru

ABSTRACT

Aim: A prospective observational study performed to find liaison between mean arterial pressure (MAP) and GFR in patients with kidney disease and to describe the gender – specific prevalence. Objectives  To find relationship between MAP and GFR in patients with HTN and CKD.  Check the prevalence of MAP in males and females.  Comparison between Hemodialysis and Non- dialysis patients correlating MAP and GFR. Background: Low Mean arterial pressure can cause low renal blood flow and may cause damage to the kidneys. However, it is not clear in the general population whether or not low renal function is related to MAP. The present study examined the liaison between MAP and Glomerular filtration rate in patients undergoing hemodialysis treatment and in patients undergoing Non-dialysis treatment aged above 18 years. Methodology:A prospective observational study was performed on patients with chronic kidney disease (CKD) at Aster Prime hospital for duration of 6 months. 90 patients with chronic kidney disease were evaluated. The source of data collection was through case sheets and lab reports. Results Before Dialysis: Correlation between MAP1 and GFR in hemodialysis patients was performed and the results demonstrated that MAP1 and GFR are significantly negatively correlated (r = -0.624) and sig.(2 tailed) p value is less than 0.05 that is it is statistically significant. After Dialysis: Correlation between MAP2 and GFR in hemodialysis patients was performed and the results demonstrated that the MAP2 and GFR are significantly negatively correlated(r = -0.394) and sig.(2 tailed) p value is less than 0.05 that is it is statistically significant. Non- Dialysis: Correlation between MAP and GFR was performed and the results demonstrated that the MAP and GFR with correlation value (r = -0.074) and sig.(2 tailed) p value is more than 0.05 that is it is statistically not significant. Conclusion: Mean arterial pressure was associated with decreased GFR in patients undergoing hemodialysis, whereas the MAP was not associated with decrease in GFR in patients undergoing non- dialysis treatment.

Keywords: Chronic Kidney disease (CKD), Mean arterial pressure (MAP), glomerular filtration rate (GFR), liaison, hemodialysis, non- dialysis.