European Journal of Biomedical and Pharmaceutical Sciences

A POTENTIAL ROLE OF ISOPRINOSINE IN PROPHYLAXIS AND EARLY TREATMENT OF COVID-19

Andrew Zakaria Zaka*, Elhassan Ahmed Mohamed, Ahmed Abdelfattah and Elhussein Ahmed Mohamed

ABSTRACT

By the end of 2019, reports of a cluster of patients infected with a novel coronavirus emerged from Wuhan, China. From then on, rapid spread of infection occurred around the world and the end of this pandemic is still beyond scope. The emerging disease, coronavirus disease 2019 (COVID-19) has variable clinical presentations ranging from asymptomatic, mild pneumonia to life threatening acute respiratory distress syndrome, septic shock, and multiple organ failure. lymphopenia is a common finding in COVID-19 and this phenomenon is more obvious in ICU patients. Isoprinosine is a synthetic compound with immunomodulatory and antiviral properties. Based on its rapidly induced lymphoproliferative responses, isoprinosine may have a potential role in prophylaxis and early treatment of COVID-19.

Keywords: COVID-19, Isoprinosine, cytokine storm, lymphopenia.