European Journal of Biomedical and Pharmaceutical Sciences

NEGLECTED TROPICAL DISEASE, LEISHMANIASIS - A REVIEW ON SYNTHETIC STRATEGIES

Amruta S. Khurd* and Pankaj B. Miniyar

ABSTRACT

Leishmaniasis is the neglected tropical diseases in several regions of the world and regarded as a serious hazard to public health. Major disease causing species include Leishmania donovani (L.donovani), Leishmania infantum (L. infantum), Leishmania braziliensis (L. braziliensis), Leishmania chagasi(L.chagasi), Leishmania amazonensis (L. amazonensis) among many other. Many natural and synthetic antileishmanial molecules have been described for disease treatment. Meticulous inspection and observation of scientific reports revealed that considerable molecules belonged to the heterocycles such as acridines, triazole, pyrazole, imidazole, indole, pyrimidi , β-carboline, quinoxaline, quinazoline and benzimidazole. In this present review, synthetic schemes of acridine molecules and metal complexes with special emphasis on structure activity relationship and antileishmanial activity in the form of IC50 values in comparison with reference standard like Amphotericin B of acridine molecules and metal complexes is discussed about.

Keywords: Leishmaniasis, acridines, metal complexes.